A low-estrogen patch made
for 7-day wear

Gwyn Lo delivers low estrogen in a once-weekly, highly adhesive transdermal patch1

220 mcg daily norelgestromin dose. 20 mcg daily ethinyl estradiol dose. Effective drug delivery depends on secure adhesion
220 mcg daily norelgestromin dose. 20 mcg daily ethinyl estradiol dose. Effective drug delivery depends on secure adhesion

Intentionally made with a low-
estrogen dose

A birth control patch worn on the stomach

Proven adhesion in a low-profile
design

~99% of the 39,790 patches worn in the year-long phase 3 study
remained attached.1

  • 1.3% of patches fully detached over the 7-day wear period1

Evaluated in real-world activities

94% of 342 patches worn in 4 additional studies had ≥75% surface area adhesion when evaluated throughout the 7-day wear period across various application sites and conditions.1

Treadmill

Sauna

Hot tub

Women should check their patch daily and after any water exposure (such as bathing or showering) to make sure all edges are sticking correctly.1

Once-weekly application

3 weeks on. 1 week off.1

Gwyn Lo follows a 28‑day regimen1:

Week 1 apply the first patch; Week 2 replace with new patch; Week 3 replace with the new patch; Week 4 patch-free week

Four application sites1

Upper back
Upper arm
Lower abdomen
Buttock

No notable differences in subject-related patch adhesion score were found based on
application sites.1

Patients should apply each patch once a week on the same day of the week, rotating the exact
application site.* Only 1 patch should be worn at a time.1

*Patients may use the same body region each week but should rotate the exact application site.1
Please see the Instructions for Use for more dosing and administration information.

Designed to provide consistent delivery over 7 days of wear

A pharmacokinetic study evaluated EE and NGMN exposure over a 7-day wear period following a single application on the lower abdomen (n=28).1

Mean EE and NGMN plasma concentrations of Gwyn Lo2

Line graphs showing mean ethinyl estradiol (EE) and norelgestromin (NGMN) plasma concentrations following a single application of Gwyn Lo over 11 days. EE concentrations rise to approximately 24 pg/mL by Day 2, remain relatively stable through Day 7, then decline after patch removal. NGMN concentrations rise to approximately 1,000 pg/mL by Day 3, gradually decrease through Day 7, and decline further after patch removal through Day 11.

No daily peaks and troughs1

Transdermal delivery
bypasses the GI tract1

EE and NGMN
reach peak by ~90 hours1

EE=ethinyl estradiol; GI=gastrointestinal; NGMN=norelgestromin.